Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000070.xml
Download PDF
Semin Musculoskelet Radiol 2002; 06(4): 285-298
DOI: 10.1055/s-2002-36727
DOI: 10.1055/s-2002-36727
Drug-Induced Metabolic Bone Disorders
Further Information
Publication History
Publication Date:
22 January 2003 (online)
ABSTRACT
A number of drugs, either physician prescribed or those taken without the knowledge of the physician, may have metabolic effects on, and result in abnormal changes in, the musculoskeletal system. These medications may involve the developing fetus, infant, child, or adult and may manifest as drug-induced embryopathies, osteoporosis, osteomalacia, or rickets, or a combination of these, or they may be associated with proliferative changes. Not uncommonly, the radiologist may be the first physician to identify the metabolic manifestations of these medications. The radiological changes associated with such drugs will be reviewed. Certain drugs may have teratogenic effects, nonteratogenic effects, or both. These effects, dependent solely on the timing of administration, will be discussed separately.
KEYWORD
Congenital abnormality,osteoporosis - rickets - osteomalacia - periostitis - proliferative enthesopathy
REFERENCES
- 1 Forfar J O, Nelson M M. Epidemiology of drugs taken by pregnant women: drugs that may affect the fetus adversely. Clin Pharmacol Ther . 1973; 14 632-642
- 2 McBride W G. Thalidomide and congenital abnormalities. Lancet . 1961; 2 1358
- 3 McCredie J, McBride W G. Some congenital abnormalities: possibly due to embryonic peripheral neuropathy. Clin Radiol . 1973; 24 204-211
- 4 McCredie J, Willert H G. Longitudinal limb deficiencies and the sclerotomes. An analysis of 378 dysmelic malformations induced by thalidomide. J Bone Joint Surg Br . 1999; 81 9-23
- 5 Rocha J. Thalidomide given to women in Brazil. BMJ . 1994; 308 1061
- 6 American Academy of Pediatrics Committee on Drugs. Anticonvulsants and pregnancy. Pediatrics . 1979; 63 331-333
- 7 Jick S S, Terris B Z. Anticonvulsants and congenital malformations. Pharmacotherapy . 1997; 17 561-564
- 8 Canger R, Battino D, Canevini M P. Malformations in offspring of women with epilepsy: a prospective study. Epilepsia . 1991; 40 1231-1236
- 9 Waziri M, Ionasescu V, Zellweger H. Teratogenic effect of anticonvulsant drugs. Am J Dis Child . 1976; 130 1022-1023
- 10 Wood P B, Young L W. Pseudo-hyperphalangism in fetal dilantin syndrome. Radiology . 1979; 131 371-372
- 11 Robinson P B, Harvey W, Belal M S. Inhibition of cartilage growth by the anticonvulsant drugs diphenylhydantoin and sodium valproate. Br J Exp Pathol . 1988; 69 17-22
- 12 Lammer E J, Chen D T. Retinoic acid embryopathy. N Engl J Med . 1985; 313 837-841
- 13 Bagheri M M, Burd L, Martsolf J T, Klug M G. Fetal alcohol syndrome: maternal and neonatal characteristics. J Perinat Med . 1998; 26 263-269
- 14 Jones K L, Smith D W, Ulleland C N. Patterns of malformation in offspring of alcoholic mothers. Lancet . 1973; 1267-1269
- 15 Maroteaux P, Lavollay B, Bomsell F. Chondrodysplasia punctata and maternal alcohol intoxication. Arch Fr Pediatr . 1984; 41 547-550
- 16 Iosub S, Fuchs M, Bingol N. Incidence of major congenital malformations in offsprings of alcoholics and polydrug users. Alcohol . 1985; 2 521-523
- 17 Milunsky A, Graef J W, Gaynor Jr F M. Methotrexate-induced congenital malformations. J Pediatr . 1968; 72 790-795
- 18 Buckley L M, Bullaboy C A, Leichtman L, Marquez M. Multiple congenital anomalies associated with weekly low-dose methotrexate treatment of the mother. Arthritis Rheum . 1997; 40 971-973
- 19 Viscarello R R, Ferguson D D, Nores J, Hobbins J C. Limb-body wall complex associated with cocaine abuse: further evidence of cocaine's teratogenicity. Obstet Gynecol . 1992; 80 523-526
- 20 Hannig V L, Phillips III A J. Maternal cocaine abuse and fetal anomalies: evidence for teratogenic effects of cocaine. South Med J . 1991; 84 498-499
- 21 Fourie D T, Hay I T. Warfarin as a possible teratogen. S Afr Med J . 1975; 49 2081-2083
- 22 Lamontagne J M, Leclerc J E, Carrier C, Bureau M. Warfarin embryopathy. J Otolaryngol . 1984; 13 127-129
- 23 Hall J G, Pauli R M, Wilson K M. Maternal and fetal sequelae of anticoagulation during pregnancy. Am J Med . 1980; 68 122-140
- 24 Sparber M. Diagnostically confusing complications of diphenylhydantoin therapy. Ann Intern Med . 1963; 59 914-930
- 25 Leonidas J, Brill P W, Waldman N. Antiepileptic therapy and rickets in children. Radiology . 1973; 109 409-412
- 26 Lifschitz F, Maclaren N K. Vitamin D-dependent rickets in institutionalized mentally retarded children receiving long-term anticonvulsant therapy: a survey of 288 patients. J Pediatr . 1973; 83 612-620
- 27 Dent C E, Richens A, Rowe D JF, Stamp T CB. Osteomalacia with long-term anticonvulsant therapy in epilepsy. BMJ . 1970; 4 69-72
- 28 Tolman K G, Jubiz W, Sannella J. Osteomalacia associated with anticonvulsant drug therapy in mentally retarded children. Pediatrics . 1975; 56 45-51
- 29 O'Hare J A, Duggan B, O'Driscoll B, Callaghan N. Biochemical evidence for osteomalacia with carbamazepine therapy. Acta Neurol Scand . 1980; 62 282-286
- 30 Stamp T CB. Drug and chemical-induced rickets (and osteomalacia). In: Preger L, ed. Induced Disease: Drug, Irradiation, Occupation
New York: Grune & Stratton 1980: 27-43
MissingFormLabel
- 31 Addy P. Rickets associated with anticonvulsant therapy in children with tuberous sclerosis. Arch Dis Child . 1997; 51 972-974
- 32 Mallette L E. Acetazolamide-accelerated anticonvulsant osteomalacia. Arch Intern Med . 1973; 137 1013-1017
- 33 Campbell J E, Tam C S, Sheppard H H. "Brown tumor" of hyperparathyroidism induced with anticonvulsant medication. J Can Assoc Radiol . 1977; 28 73-76
- 34 McCrea E S, Rao C V, Diaconis J N. Roengtenographic changes during long-term diphenylhydantoin therapy. South Med J . 1980; 73 312-317
- 35 Kattan K R. Calvarial thickening after dilantin medication. AJR Am J Roentgenol . 1970; 110 102-105
- 36 Harris M, Goldhaber P. Root abnormalities in epileptics and the inhibition of parathyroid hormone induced bone resorption by diphenylhydantoin in tissue culture. Arch Oral Biol . 1974; 19 981-984
- 37 Kattan K R. Thickening of the heel-pad associated with long-term dilantin therapy. AJR Am J Roentgenol . 1975; 124 52-56
- 38 De Virgiliis S, Congia M, Frau F. Deferoxamine-induced growth retardation in patients with thalassemia major. J Pediatr . 1988; 113 666-669
- 39 Brill P W, Winchester P, Giardina P J, Cunningham-Rundles S. Deferoxamine-induced bone dysplasia in patients with thalassemia major. AJR Am J Roentgenol . 1991; 156 561-565
- 40 Orzincolo C, Scutellari P N, Castaladi G. Growth plate injury of the long bones in treated β-thalassemia. Skeletal Radiol . 1992; 21 39-44
- 41 Chan Y, Li C, Chu W C, Cheng J C, Chik K W. Deferoxamine-induced bone dysplasia in the distal femur and patella of pediatric patients and young adults: MR imaging appearance. AJR Am J Roentgenol . 2000; 175 1561-1566
- 42 Chan Y L, Li C K, Pang L M, Chik K W. Deferoxamine-induced long bone changes in thalassemic patients-radiographic features, prevalence and relations with growth. Clin Radiol . 2000; 55 610-614
- 43 Nagant de Deuxchaisnes C, Rombouts-Lindemans C, Huaux J P. Paget's disease of bone. BMJ . 1981; 283 1054-1055
- 44 Wood B J, Robinson G C. Drug induced changes in myositis ossificans progressiva. Pediatr Radiol . 1976; 5 40-43
- 45 Gallacher S J, Boyle I T, Capell H A. Pseudogout associated with the use of cyclical etidronate therapy. Scott Med J . 1991; 36 49
- 46 van Dyke J J, Falkson H C, van der Merve M A. Unexpected toxicity in patients treated with iphosphamide. Cancer Res . 1972; 32 921-924
- 47 Sweeney L E. Hypophosphatemic rickets after ifosfamide treatment in children. Clin Radiol . 1993; 47 345-347
- 48 Heaf J G, Nielsen L P. Serum aluminium in haemodialysed patients: relation to osteodystrophy, encephalopathy and aluminium hydroxide consumption. Miner Electrolyte Metab . 1984; 10 345-350
- 49 Mjoberg B. Aluminium-induced hip fractures: a hypothesis. J Bone Joint Surg Br . 1989; 71 538
- 50 Freundlich M, Zilleruelo G, Abitol C. Infant formula as a cause of aluminium toxicity in neonatal uraemia. Lancet . 1985; 2 527-529
- 51 Andreoli S P, Smith J A, Bergstein J M. Aluminum bone disease in children: radiographic features from diagnosis to resolution. Radiology . 1985; 156 663-667
- 52 Hernandez R J, Sedman A B, Smid D M, Goodman W G. Radiographic manifestations of experimental aluminum toxicity in growing bone. Skeletal Radiol . 1987; 16 209-215
- 53 Llewellyn C H, Resnik C S, Brower A C. Case report 288. Skeletal Radiol . 1984; 12 223-226
- 54 Greenwood R H, Prunty F TG, Silver J. Osteomalacia after prolonged glutethimide administration. BMJ . 1973; 1 643-645
- 55 Lamm C I, Norton K I, Murphy R JC, Wilkins I A, Rabinowitz J G. Congenital rickets associated with magnesium sulfate infusion for tocolysis. J Pediatr . 1980; 113 1078-1082
- 56 Brodie M J, Boobis A R, Dollery C T. Rifampicin and vitamin D metabolism. Clin Pharmacol Ther . 1980; 27 810-814
- 57 Heaton K W, Lever J V, Barnard D. Osteomalacia associated with cholestyramine therapy for postiliectomy diarrhoea. Gastroenterology . 1972; 62 642-646
- 58 Frame B, Guing H L, Frost H M, Reynolds W A. Osteomalacia induced by laxative (phenolphthalein) ingestion. Arch Intern Med . 1971; 128 794-796
- 59 Neumann L, Jenson B G. Osteomalacia from aluminium and magnesium antacids. Report of a case of bilateral hip fracture. Acta Orthop Scand . 1989; 60 361-362
- 60 Chudley A E, Brown D R, Holzman I R, Sang Oh K. Nutritional rickets in two very low birth weight infants with chronic lung disease. Arch Dis Child . 1980; 55 687-690
- 61 Binstadt D H, L'Heureux P R. Rickets as a complication of intravenous hyperalimentation in infants. Pediatr Radiol . 1978; 7 211-214
- 62 Gefter W B, Epstein D M, Anday E K, Dalinka M K. Rickets presenting as multiple fractures in premature infants on hyperalimentation. Radiology . 1982; 142 371-374
- 63 Sambrook P N, Birmingham J, Kempler S. Corticosteroid effects on proximal bone femur bone loss. J Bone Miner Res . 1990; 5 1211-1216
- 64 Gennair C, Citivelli R. Glucocorticoid-induced osteoporosis. Clin Rheum Dis . 1986; 12 637-654
- 65 Luengo M, Picado C, Del Rio L. Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study. Thorax . 1991; 46 803-806
- 66 Gluck O S, Murphy W A, Hahn T J, Hahn B H. Bone loss in adults receiving alternate day glucocorticoid therapy: a comparison with daily therapy. Arthritis Rheum . 1981; 24 892-898
- 67 Murray R O. Radiological bone changes in Cushing's syndrome and steroid therapy. Br J Radiol . 1960; 33 1-19
- 68 Maldague B E, Noel H M, Malghem J. The intravertebral vacuum cleft: a sign of ischaemic vertebral collapse. Radiology . 1978; 129 23-29
- 69 Ragab A H, Frech R S, Vietti T J. Osteoporotic fractures secondary to methotrexate therapy of acute leukemia in remission. Cancer . 1970; 25 580-585
- 70 Jaffe M D, Willis P W. Multiple fractures associated with long-term sodium heparin therapy. JAMA . 1965; 193 152-154
- 71 Caffey J. Chronic poisoning due to excess of vitamin A. AJR Am J Roentgenol . 1951; 65 12-26
- 72 Pittsley R A, Yoder F W. Retinoid hyperostosis: skeletal toxicity associated with long-term administration of 13-cis-retinoic acid for refractory ichthyosis. N Engl J Med . 1983; 308 1012-1014
- 73 Lawson J P, McGuire J. The spectrum of skeletal changes associated with long-term administration of 13-cis-retinoic acid. Skeletal Radiol . 1987; 16 91-97
- 74 Di Giovanna J J, Helffgott R K, Gerber L H, Peck G L. Extraspinal tendon and ligament calcification associated with long-term therapy with etretinate. N Engl J Med . 1986; 315 1177-1182
- 75 Vilon P, Fiche M, Maugars Y. Sarcome Parosteal du radius apparu lors d'un traitement par etretinate. Rev Rhum . 1991; 58 825-827
- 76 Elliott R B, Starling M B, Neutze J M. Medical manipulation of the ductus arteriosus. Lancet . 1975; 1 140-142
- 77 Ueda K, Saito A, Nakano H. Cortical hyperostosis following long-term administration of prostaglandin E1 in infants with cyanotic congential heart disease. J Pediatr . 1980; 97 834-836
- 78 Hoevels-Guerich H, Haferkorn L, Persigehl M. Widening of cranial sutures after long-term prostaglandin E2 infusion in two newborn infants. J Pediatr . 1984; 105 72-74
- 79 Teotia S P, Teotia M. Secondary hyperparathyroidism in patients with endemic fluorosis. BMJ . 1973; 1 637-640
- 80 Schulz E E, Engstrom H, Sauser D D, Baylink D J. Osteoporosis: radiographic detection of fluoride-induced extra-axial bone formation. Radiology . 1986; 159 457-462
- 81 Gerster J C, Charhon S A, Jaeger P. Bilateral fractures of the femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis. BMJ . 1983; 287 723-725
- 82 Pak C Y. Fluoride and osteoporosis. Proc Soc Exp Biol Med . 1989; 191 278-286
- 83 Bregeon C h, Bernat M, Renier J-C, Rebel A, Basile M. Osteose fluoree après 11 ans de traitement ininteruptee par l'acide niflumique. Nouv Presse Med . 1980; 9 1446-1447